A case of gastric cancer with multiple liver metastases that were completely responsive to hepatic arterial infusion chemotherapy
Tamamori, Y.; Nishino, H.; Yamada, N.; Nishihara, T.; Tanaka, H.; Nakazawa, K.; Hirakawa, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(11): 1736-1739
2001
ISSN/ISBN: 0385-0684 PMID: 11708021 Document Number: 538966
A 70-year-old male was hospitalized with a diagnosis of gastric cancer. Multiple liver metastases were detected by CT scan and ultrasonography, but no other metastases were found. After distal gastrectomy with lymphadenectomy, an intra-arterial catheter was inserted and hepatic arterial infusion (HAI) chemotherapy was started with the following regimen: epirubicin, 40 mg (once in 4 weeks); MMC, 4 mg (once in 2 weeks); and 5-FU, 500 mg (once a week). Oral administration of 300 mg/day of tegafur-uracil (UFT) was given concurrently. The metastatic liver tumors were gradually reduced, and then disappeared. The patient has been free from recurrence after HAI. As gastric cancer tends to spread (e.g. peritoneal dissemination) more than colorectal cancer, the indication for HAI in cases of gastric cancer is limited. However, the present case suggests that it may be useful in achieving long-term survival for patients with metastases localized in the liver.