Effects and complications of continuous hepatic arterial infusion chemotherapy using implantable reservoir for liver metastases from colorectal cancer
Kurosawa, H.; Ohki, S.; Joh, T.; Imai, S.; Matsuo, K.; Yamaguchi, S.; Fukano, M.; Hasegawa, S.; Tokitoh, T.; Masui, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 18(11): 1930-1934
1991
ISSN/ISBN: 0385-0684 PMID: 1908660 Document Number: 386309
Continuous arterial infusion chemotherapy using implantable reservoir was performed for unresectable liver metastases from colorectal cancer and the therapeutic effects, side effects and complications were evaluated. Eleven patients were treated with four kinds of arterial infusion courses that mainly consisted of 5-FU. The arterial infusion courses were discontinued in 2 patients because of nausea and vomiting, and in one patient because of diarrhea. The catheters were dislocated in 2 patients and another 2 developed fistulous between the hepatic artery and bile duct. Three patients developed duodenal ulcer. Serum CEA was reduced in 4 patients (36%). After all, response rate was 9% (1/11). The one-year survival rates of all cases and cases treated with more than 4 courses were 36.3% and 80.0%, respectively.