Continuous intra-arterial infusion chemotherapy in colorectal cancer patients with nonresectable metastatic liver cancer
Watanabe, T.; Sawada, T.; Kubota, Y.; Ooya, M.; Masaki, T.; Sameshima, S.; Shinozaki, M.; Tsuno, N.; Uchiyama, M.; Sakaguchi, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 19(10 Suppl): 1515-1518
1992
ISSN/ISBN: 0385-0684 PMID: 1530298 Document Number: 396404
Five colorectal cancer patients with nonresectable metastatic liver cancer underwent continuous intraarterial chemotherapy in our institute from January to December 1991. Patients included four rectal cancers and one colonic cancer. 5-fluorouracil (5-FU) was infused continuously through an Infuse-A-Port; 360 mg/m2/day for one week after operation, and 180 mg/m2/day for the following three weeks. Since the fifth week after operation, two weeks without infusion and two weeks of infusion (180 mg/m2/day) were alternated as long as possible. Total periods of 5-FU infusion therapy were from one to 11 months and total doses of 5-FU ranged from 8,750 mg to 25,650 mg. Three patients showed partial response (PR) and two patients progressive disease (PD) (response rate; 60%). In three cases of PR, lengths of infusion therapy and total doses of 5-FU before PR was first observed was 8 weeks, 10,750 mg, 6 weeks, 9,250 mg, and 4 weeks, 8,750 mg, respectively. Four patients presented nausea, appetite loss or abdominal pain, which were considered to be side effects of 5-FU. In one of these four patients, infusion could not be continued because symptoms were so severe. However, catheter troubles were not noticed among all cases.