Evaluation of hepatic arterial infusion chemotherapy for liver metastasis from gastric cancer
Ota, T.; Shuto, K.; Ohira, G.; Natsume, T.; Saito, H.; Sato, A.; Kawahira, H.; Nabeya, Y.; Matsubara, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(12): 2019-2021
2009
ISSN/ISBN: 0385-0684 PMID: 20037310 Document Number: 634480
We performed hepatic arterial infusion (HAI) chemotherapy for 11 patients with liver metastasis from gastric cancer, who had no other metastasis. The main antineoplastic drug was 5-fluorouracil (5-FU). The catheter was inserted into the hepatic artery using the GDA coiling method by interventional radiologic technique in 9 patients, and by operative treatment in 2 patients. The response rate for 10 patients was 91% (CR 3, PR 7, PD 1). The survival time from the beginning of the HAI chemotherapy was 8-34 months. The causes of withdrawal from the chemotherapy were PD in 7 patients and catheter troubles in 4 patients. There was no patient suffering from severe adverse effect. The HAI chemotherapy was effective and useful for patients with liver metastasis of gastric cancer. We thought a gastric cancer patient with liver metastasis who didn't have an uncontrollable other organ metastasis was a good target for this regimen.