Application of PNA and LNA oligomers to chemotherapy
Elayadi, A.N.; Corey, D.R.
Current Opinion in Investigational Drugs 2(4): 558-561
2001
ISSN/ISBN: 1472-4472 PMID: 11566018 Document Number: 530960
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.
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