The search for anti-ulcer agents at IDR

Andrási, F.

Acta Pharmaceutica Hungarica 71(1): 40-43


ISSN/ISBN: 0001-6659
PMID: 11769095
Document Number: 530955
2-Pyridyl-thioacetamide (2-PTA) was synthesized at IDR in 1968. This molecule showed strong antiulcer/antisecretory effects in animals and man by inhibiting the proton pump. Based on our work Astra developed omeprazole which is the No. 1 drug in the world from 1996. 2-PTA remained a very popular template for drug design for a quarter of century.

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