Comparison of the effectiveness of anti-ulcer drugs and their influence on angiogenesis in healing of experimental chronic gastric ulcer

Hnatyszyn, A.

Annales Academiae Medicae Stetinensis 41: 183-191


ISSN/ISBN: 1427-440X
PMID: 8615543
Document Number: 453363
This study compares ulcer healing properties of pirenzepine (10 mg kg), sucralfate (400 mg/kg), famotidine (4 mg/kg), colloidal bismuth subcitrate (200 mg/kg), misoprostol (0.2 mg/kg) in rats. Colloidal bismuth subcitrate (CBS), sucralfate, famotidine and pirenzepine given orally were equally effective in the healing of chronic acetic gastric ulcers, while misoprostol was less effective in this model. In addition, the influence of these drugs on angiogenesis in the healing process of chronic acetic gastric ulcer was investigated. Angiogenesis is believed to play a significant role in the healing process of chronic gastric ulcer. Newly formed capillaries play an important role in early stages of healing, reabsorption and granulation. Abundant formation of new capillaries is especially characteristic for granulation. During scar formation these newly formed capillaries disappear. Taking into account the existence of capillaries during healing one can evaluate a quantity of newly born capillaries to describe the healing. The capillary system in histologic cross-sections has been visualized employing as enzymatic test reaction the activity of alkaline phosphatase and ATPase, which are very active in the capillary endothelium. The increased number of capillaries and their surface have been shown using computed analysis of microscopic pictures in animals that had received antiulcer drugs. (Fig. 1-4). Conclusions. (1) Histochemical methods and computed analysis of microscopic pictures used here give an objective evaluation of angiogenesis in the healing process of chronic gastric ulcers. (2) The antiulcer drugs investigated stimulate angiogenesis which is an important element of their accelerating effect on the healing of chronic gastric ulcers.

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