The influence of non-steroidal anti-inflammatory drugs (NSAID) in the treatment of peptic ulcer. a prospective randomized study
Manniche, C.; Malchow-Møller, A.
Ugeskrift for Laeger 149(32): 2143-2144
1987
ISSN/ISBN: 0041-5782 PMID: 3329789 Document Number: 304175
In 62 patients with rheumatic disease with NSAID-associated peptic ulcer, the effects of two different ulcer treatments (ranitidine or sucralphate) and the effect of continued NSAIDs on the ulcer healing process were evaluated. Within nine weeks of treatment, ulcers were healed in 23/30 (77%) of the patients who continued NSAIDs and in 29/32 (91%) of the patients in whom NSAIDs were withdrawn. The healing rates after nine weeks of treatment were 84% in patients treated with ranitidine and 83% in patients treated with sucralphate. None of the differences were statistically significant. It is suggested that NSAIDs should not be withdrawn if peptic ulceration is diagnosed in patients with rheumatic diseases in whom the rheumatic disease justifies continued treatment with NSAIDs.