Ranitidine in the treatment of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drugs
Tildesley, G.; Ehsanullah, R.S.; Wood, J.R.
British Journal of Rheumatology 32(6): 474-478
1993
ISSN/ISBN: 0263-7103 PMID: 8508283 Document Number: 412366
To assess the effect of 4 weeks' therapy with ranitidine 150 mg twice daily on the healing of symptomatic NSAID-associated gastric and duodenal ulcers, 149 arthritic patients were randomly allocated to one of three treatment groups: ranitidine with NSAID continued, ranitidine with NSAID discontinued, and placebo with NSAID discontinued. The healing frequency in patients with gastric ulceration was 67, 68 and 47%, and in those with duodenal ulceration 61, 81 and 42%, respectively. Only the difference between the duodenal ulcer healing rates for ranitidine with NSAID discontinued and placebo was statistically significant (P = 0.02). Healing rates were uninfluenced by gender, age, smoking habits, alcohol consumption, ulcer frequency or size, arthritic disease, or participating country.