Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones
Bozdağ, O.; Verspohl, E.J.; Ertan, R.
Arzneimittel-Forschung 50(7): 626-630
2000
ISSN/ISBN: 0004-4172 PMID: 10965419 Document Number: 525964
A new series of 3'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized and their chemical structures have been elucidated by various spectral data. The prepared compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1 and 2. In contrast compounds 4, 7 and 8 were able to increase insulin release compared with glibenclamide.
Document emailed within 1 workday
Related Documents
Zubchenko, V.G.; Kulik, M.I. 1973: Synthesis of azolidine derivatives with possible hypoglycemic action. IX. 2'-Arylsulfonyl-3-aryl-(alkyl-) derivatives of 2-iminothiazolidone-4 Farmatsevtychnyi Zhurnal 28(5): 28-33Vicini, P.; Amoretti, L.; Caretta, A. 1992: Synthesis, hypoglycemic and toxicological evaluation of new 1,2-benzisothiazolyl derivatives Farmaco 47(3): 265-274
Polacek, I.; Ouart, J. 1978: Hypoglycemic activity of amine derivatives. a possible mode of action Arzneimittel-Forschung 28(6): 984-989
Polacek, I.; Breuer, H. 1978: Hypoglycemic activity of amine derivatives. Preliminary observations Arzneimittel-Forschung 28(5): 791-793
Brzozowski, Z.; Magiełka, S.; Wójcikowski, C. 1983: Derivatives of pyrazole-l-carboxylic acid. VII. Synthesis and hypoglycemic properties of various N-(4-[2-(alkyl-2-pyrazoline-1-carbonamido)-ethyl]-benzenesulfonyl)-N'-cyclohexylurea Acta Poloniae Pharmaceutica 40(2): 134-138
Alunni Bistocchi, G.; De Meo, G.; Pedini, M.; Ricci, A.; Bastianini, L.; Sposini, T.; Sbaraglia, G.; Jacquignon, P. 1986: New heterocyclic derivatives of benzimidazole with germicidal activity. III. Synthesis and activity of derivatives of (formyl-5'-furyl-2')-2-benzimidazole with different substitutions at position 5 Il Farmaco; Edizione Scientifica 41(12): 970-983
Foks, H.; Janowiec, M. 1978: Pyrazine derivatives. XI. Synthesis and tuberculostatic activity of derivatives of pyrazineurea and pyrazinethiourea Acta Poloniae Pharmaceutica 35(5): 615-618
Pancechowska-Ksepko, D.; Foks, H.; Landowska, E.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XVII. Synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives Acta Poloniae Pharmaceutica 43(2): 116-123
Milczarska, B.; Foks, H.; Trapkowski, Z.; Milzyńska-Kołaczek, A.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1998: Studies on pyrazine derivatives. XXXII. Synthesis and tuberculostatic activity of acetylpyrazine thiosemicarbazone derivatives Acta Poloniae Pharmaceutica 55(4): 289-295
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Rudnicka, W.; Foks, H.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XXI. Synthesis and tuberculostatic activity of 4-aryl-1-pyrazinoylthiosemicarbazides and the products of their cyclization to 1,2,4-triazole-3-thione derivatives Acta Poloniae Pharmaceutica 43(6): 523-528
Milczarska, B.; Foks, H.; Mikołajczyk, K.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 2000: Studies on pyrazine derivatives--XXXIV. Synthesis and tuberculostatic activity of alpha-oxo ketene dithioacetals pyrazine derivatives Acta Poloniae Pharmaceutica 57(4): 307-310
Wu, K.; Tong, Z.S.; Dai, C.S.; Li, L.; Zheng, S.X. 1993: Synthesis and bio-activity of coumarin derivatives and studies on its relationships between activity and lipophilicity Yao Xue Xue Bao 28(4): 266-272
Kunoh, Y.; Iguchi, A.; Gotoh, M.; Nomura, T.; Shibata, M.; Sakamoto, N. 1986: Hypoglycemic activity of MTP-1403 (2-amino-7,8-dihydro-4-piperazinyl-6H-thiopyrano 3,2-d pyrimidine), a new hypoglycemic agent Archives Internationales de Pharmacodynamie et de Therapie 280(2): 302-313
Alcalde, E.; Maños, L.; Dinares, I.; Valls, N.; Elguero, J.; Escario, J.A.; Martinez, A.R.; Igea, A.; Osuna, A.; Ruiz-Perez, L.M. 1989: New derivatives of 5-nitroimidazole: synthesis and antiparasitic activity Farmaco 44(11): 1095-1107
Kornicka, A.; Hudson, A.L.; Bednarski, P.J. 2009: Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives Acta Poloniae Pharmaceutica 66(5): 523-534
Krepelka, J.; Kotva, R.; Vachek, J.; Holubek, J.; Mĕlka, M.; Maturová, E.; Grimová, J. 1986: Synthesis and pharmacologic activity of pyrimidine derivatives Ceskoslovenska Farmacie 35(10): 433-439
Dupin, J.P.; Gryglewski, R.J.; Gravier, D.; Hou, G.; Casadebaig, F.; Swies, J.; Chlopicki, S. 2002: Synthesis and thrombolytic activity of new thienopyrimidinone derivatives Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 53(4 Part 1): 625-634
Aboul-Enein, M.N.; El-Difrawy, S.M.; Nofal, Z.M.; El-Azzouny, A.A.; El-Hawary, S. 1982: Synthesis and antimicrobial activity of 2-arylmethylpyrrolidine derivatives Acta Pharmaceutica Suecica 19(4): 309-316
Sridhar, S.K.; Pandeya, S.N.; De Clercq, E. 2001: Synthesis and anti-HIV activity of some isatin derivatives Bollettino Chimico Farmaceutico 140(5): 302-305