Synthesis, hypoglycemic and toxicological evaluation of new 1,2-benzisothiazolyl derivatives
Vicini, P.; Amoretti, L.; Caretta, A.
Farmaco 47(3): 265-274
1992
ISSN/ISBN: 0014-827X PMID: 1503591 Document Number: 389695
The synthesis of 1,2-benzisothiazol-3-ylguanidines, 1,2-benzisothiazol-3-ylbenzensulphonylureas and 1,2-benzisothiazol-3-ylbenzensulphonamides is described. Some of the new compounds showed moderate hypoglycemic activity but most of them caused serious acute toxic effects.
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