Determination of xanthinol nicotinate in drug preparations using capillary isotachophoresis
Pospísilová, M.; Jokl, V.; Dolejsová, J.
Ceska a Slovenska Farmacie Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti 49(2): 88-90
2000
ISSN/ISBN: 1210-7816 PMID: 10953450 Document Number: 525909
Cationic capillary isotachophoresis (ITP) with coductimetric detection has been used for separating and determination of xanthinol in two commercial mass-produced preparations. The optimized ITP electrolyte system consisted of 5 mM potassium picolinate + 5 mM picolinic acid (pH 5.21) as the leading electrolyte and 10 mM formic acid as the terminating electrolyte. The driving and detection currents were 50 microA (for 380 s) and 10 microA, respectively. The analysis took about 8 min. According to the validation procedure based on the reference UV spectrophotometric method, the ITP method gave practically the same results.