Thrombolytic and antiplatelet action of xanthinol nicotinate (Sadamin) : possible mechanisms
Bieroń, K.; Swies, J.; Kostka-Trabka, E.; Gryglewski, R.J.
Journal of Physiology and Pharmacology An Official Journal of the Polish Physiological Society 49(2): 241-249
1998
ISSN/ISBN: 0867-5910 PMID: 9670107 Document Number: 495452
Here we report on thrombolytic and hypotensive actions of Xanthinol nicotinate (Sadamin) in rats and on its anti-platelet and fibrinolytic effects in patients with peripheral arterial obliterative disease (PAOD). Special-consideration was given to a proposal of new mechanisms of anti-platelet and thrombolytic actions of Sadamin. We conclude that the mechanism of anti-platelet and thrombolytic activity of Sadamin partly consists of a simultaneous release of endogenous prostacyclin and nitric oxide by the nicotinate component of Sadamin, whereas the theophylline component is responsible for enhancement of physiological actions of these endothelial mediators at the level of cyclic nucleotides which are their second messengers.