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Study of lipid peroxidation inhibition in human blood by several endogenous and exogenous compounds

Dailly, E.

Annales Pharmaceutiques Francaises 58(5): 303-307

2000

ISSN/ISBN: 0003-4509
PMID: 11060406
Document Number: 520204
Numerous studies suggest that lipid peroxidation is involved in the atherosclerosis and hemolytic disease processes. Nicanartine improves in vitro resistance of LDL (low density lipoproteins) to oxidation in the conjugated dienes model. Polarographic assays show that hemin-bound drugs inhibit erythrocyte membrane peroxidation. A method to measure the antioxidant capacity of plasma is proposed and tested in sickle cell disease. These in vitro results suggest drugs and drugs combination which could be efficient to inhibit lipid peroxidation in vivo.

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