Ranitidine, cimetidine, antacids, and gastro-oesophageal reflux: results of a 20-hour oesophageal pH study
Desechalliers, J.P.; Galmiche, J.P.; Touchais, J.Y.; Denis, P.; Colin, R.
International Journal of Clinical Pharmacology Research 4(3): 217-222
1984
ISSN/ISBN: 0251-1649 PMID: 6092288 Document Number: 515
The effects of cimetidine, ranitidine and antacids on esophageal pH levels were compared. Patients (45) were confirmed as having a gastro-esophageal acid reflux by 3-h postprandial metered pH measurements. The 45 patients were randomly placed into 3 treatment groups; 1 group received cimetidine 1 g/day, the 2nd received ranitidine 300 mg/day and the 3rd received 60 ml/day of an antacid. The patients were retested under treatment (3-h postprandial metered pH and prolonged 20-h metered pH). The 3-h postprandial metered pJH was then compared to the pretreatment tests. The 20 h postprandial metered pH test was compared with the results from 43 control (untreated) subjects with gastro-esophageal acid refluxes. The 3 h postprandial comparison showed a significant decrease in acid reflux with all 3 treatment drugs. The 20 h measurement demonstrated a significant decrease with all 3 drugs in the number of acid reflux incidences compared to the untreated control patients; the ranitidine group had a significant decrease in the percentage of time with acid pH. No significant differences appeared in the comparison of records of the 45 treated patients except for the percentage of time below pH 2 for 20 h which was significantly lower for ranitidine. All 3 treatments were effective with a clear advantage in favour of ranitidine.
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