Effect of cimetidine in symptomatic gastro-oesophageal reflux
Powell-Jackson, P.; Barkley, H.; Northfield, T.C.
Lancet 2(8099): 1068-1069
1978
ISSN/ISBN: 0140-6736 PMID: 82086 Document Number: 134932
Patients (27) with symptomatic gastro-esophageal reflux received cimetidine 1.6 g daily for 6 wk and matching placebo for 6 wk in a randomized double-blind crossover trial. They complained of significantly more episodes of pain on placebo than on cimetidine (1186 vs. 581) and consumed significantly more antacid tablets on placebo than on cimetidine (1645 vs. 1011). Cimetidine and placebo had similar effects on mucosal sensitivity to acid and on esophagitis assessed endoscopically and histologically, suggesting that the symptomatic benefit is the result of a simple antacid effect.