Influence of cisapride on food-stimulated gastro-oesophageal reflux: a radiological study
Gelineck, J.; Aksglade, K.; Funch-Jensen, P.; Thommesen, P.
Rontgen-Blatter; Zeitschrift für Rontgen-Technik und Medizinisch-Wissenschaftliche Photographie 43(8): 352-354
1990
ISSN/ISBN: 0300-8592 PMID: 2204995 Document Number: 359650
The influence of Cisapride on food-stimulated gastro-oesophageal reflux mechanisms was studied in a double-blinded cross-over investigation in 24 consecutive patients selected by endoscopy, 12 with microscopical evidence of gastro-oesophageal reflux and 12 with additional macroscopic oesoghagitis. 63% had food-stimulated gastro-oesophageal reflux, and Cisapride significantly reduced the tendency to gastro-oesophageal reflux and mucosal contact time between gastric content and the oesophageal mucosa in 73% of these patients. It is concluded that Cisapride could be valuable in the treatment of gastro-oesophageal reflux.