The determination of clozapine in blood and urine by gas chromatography-mass spectrometry
Melent'ev, A.B.; Kurochkina, I.V.
Sudebno-Meditsinskaia Ekspertiza 42(4): 27-29
1999
ISSN/ISBN: 0039-4521 PMID: 10467865 Document Number: 504377
A method for measuring closapine in the blood and urine by gas chromatography-mass spectrometry as a trifluoroacetic derivative is proposed. The threshold level for closapine detection is 25 ng/ml in the blood and 30 ng/ml in the urine. Calibration curves are linear in the range 0.025-5 mcg/ml for the blood and 0.03-50 mcg/ml for the urine. The method can be used in forensic chemical and clinical toxicological analysis.
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