Absorption and excretion of tritiated haloperidol in man. (A preliminary report)
Johnson, P.C.; Charalampous, K.D.; Braun, G.A.
International Journal of Neuropsychiatry 3(Suppl 1): 24-25
1967
ISSN/ISBN: 0538-8163 PMID: 6051722 Document Number: 4942
As with the phenothiazine derivatives extrapyramidal symptoms were common side effects. All the patients in the schizophrenic group developed Parkinsonism symptoms while taking the drug. It is possible that the rapid onset of pharmacologic activity following treatment with haloperidol may be caused by a less efficient means of metabolizing haloperidol as compared with the phenothiazines. Metabolic degradation is known to occur in rats but information in the human is not yet available.
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