Effect of alpha-tocopherol and its derivatives on the viability of cultured malignant cells
Donchenko, G.V.; Kholodova, I.D.; Kuz'menko, I.V.; Klimenko, E.P.
Ukrainskii Biokhimicheskii Zhurnal 70(2): 37-45
1998
ISSN/ISBN: 0201-8470 PMID: 9848159 Document Number: 493161
The effect of alpha-tocopherol and its derivatives on viability and growth of attached cells culture: human epithelioid carcinoma of cervix HeLa-S3K and human cervical carcinoma cell line C-4-1 according to protein content and level of alkaline phosphatase, as well to unattached cells: human acute leukemia cell cultures CEM-C-1 and CEM-C-7 according to the amount of viable cells in suspension has been studied. It has been shown that alpha-tocopherol acetate and tocopherol maintain the viability of cells, while the derivatives of tocopherol with shorted side chain considerably inhibit growth of researched cultures, alpha-tocopherol with lacking side chain being most active among them.