Effect of alpha-tocopherol and ubiquinone on mitochondrial RNA polymerase activity. the role of tocopherol-binding proteins
Petrova, G.V.; Kapralov, A.A.; Izhokina, I.A.; Donchenko, G.V.
Biokhimiia 59(4): 575-581
1994
ISSN/ISBN: 0320-9725 PMID: 8018780 Document Number: 434465
It has been shown that alpha-tocopherol within the complex with tocopherol-binding proteins, in contrast with free tocopherol, decreases the RNA-polymerase activity in isolated rat liver mitochondria. Both free and complexed to proteins alpha-tocopherol increases the RNA-polymerase activity in isolated nuclei. The effect of alpha-tocopherol is conditioned mostly by the nature of the tocopherol-binding proteins. It has been established that ubiquinone complexed to tocopherol-binding proteins from mitochondria can also change the level of RNA synthesis. The effect of alpha-tocopherol and ubiquinone are not additive.