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Effect of oxygen radicals on heart mitochondrial function in alpha-tocopherol deficient rabbits

Flamigni, F.; Guarnieri, C.; Toni, R.; Caldarera, C.M.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 52(4): 402-406

1982

ISSN/ISBN: 0300-9831
PMID: 7160967
Document Number: 189850
The mitochondria extracted from hearts of alpha-tocopherol deficient rabbits showed a decreased mitochondrial function and an increased formation of oxygen radicals associated with a decreased superoxide dismutase activity. The exposure of the alpha-tocopherol deficient mitochondria to exogeneous oxygen radicals caused a marked decrease in the mitochondrial function with respect to control mitochondria, which was partially reversed by the addition in vitro of alpha-tocopherol.

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