Effect of octreotide on the clinical course of acute pancreatitis and levels of free oxygen radicals and antioxidants
Lata, J.; Dítĕ, P.; Julínková, K.; Precechtĕlová, M.; Prásek, J.
Vnitrni Lekarstvi 44(9): 524-527
1998
ISSN/ISBN: 0042-773X PMID: 10358462 Document Number: 495709
Twenty-one patients with a medium severe form of acute pancreatitis were divided into two groups. Eleven were treated with octreotide, 200 micrograms s.c. every 8 hours, combined with standard conservative treatment, 10 patients had the same treatment but without octreotide. In the octreotide-treated group the level of free oxygen radicals and important antioxidants--vitamins A, E and C--was assessed. In the octreotide-treated group the authors found after five days normal levels of originally elevated free oxygen radicals and a significant increase of the vitamin C level. As compared with the control group, in the octreotide group the period of hospitalization was significantly shorter (9.8 +/- 3.2 vs. 13.7 +/- 4.7). The number of complications was not affected.