Antioxidant probucol: effects on free radical lipid peroxidation, blood rheology and course of angina pectoris
Zakirova, A.N.; Shamaev, A.G.; Mirionkova, N.A.
Terapevticheskii Arkhiv 70(1): 29-32
1998
ISSN/ISBN: 0040-3660 PMID: 9532648 Document Number: 491388
Study of the effect of antioxidant probucol on free-radical lipid peroxidation, blood rheology, and course of angina pectoris in coronary patients. The above parameters and clinical hemodynamic values were monitored over the course of probucol therapy in 48 men (mean age 54.8 +/- 1.3 years) with coronary disease and angina of effort of the II-III functional class. Long therapy with probucol effectively inhibited free-radical lipid peroxidation, normalized lipid spectrum of the blood, and had a favorable impact on the course of angina pectoris. Probucol stabilizes the structure and function of red cells and platelets in coronary patients.