A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension

Bolzano, K.; Krempler, F.; Sandhofer, F.

Acta Medica Austriaca 11(2): 49-53

1984


ISSN/ISBN: 0303-8173
PMID: 6377793
Document Number: 4913
41 patients (35 males and 6 females) with moderate hypertension were treated with a combination of methyldopa/hydrochlorothiazide/amiloride (M/HCT/A). In a double blind study the blood-pressure-lowering effect of this combination was compared with the effect of M or HCT/A alone. After 8 weeks of treatment, the combination of M/HCT/A lowered the elevated blood pressure more efficiently than the two monotherapies . M counteracted the potassium-loosing effect of HCT/A, but did not prevent the elevation of serum urea, creatinine and uric acid which is observed under treatment with HCT/A.

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A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension