Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application
Blazsó, G.; Gábor, M.; Rohdewald, P.
Die Pharmazie 52(5): 380-382
1997
ISSN/ISBN: 0031-7144 PMID: 9183789 Document Number: 483815
Procyanidin-containing extracts from the fresh bark of P. pinaster administered orally in liquid diet significantly decreased the croton oil-induced ear oedema in mice or the compound 48/80-induced hind paw oedema in rats. Most effective were the extracts containing mainly oligomeric procyanidins with chain lengths greater than 4 units. The different extracts incorporated in various concentrations (1, 3 or 0.1%) in 5% hydroxyethylcellulose gel and applied topically on the shaved back of rats, inhibited significantly the ultraviolet radiation-induced increased capillary permeability. In these experiments, normalization of capillary permeability was not correlated with the content in the extracts of higher oligomeric procyanidins.