Biologically active peptide fragments of functional proteins produced by proteolysis in vitro
Filippova, M.M.; Karelin, A.A.; Ivanov, V.T.
Bioorganicheskaia Khimiia 23(5): 388-409
1997
ISSN/ISBN: 0132-3423 PMID: 9290050 Document Number: 476904
Over 100 various peptides were identified as a result of numerous studies of in vitro proteolytic digestion of some proteins and tissue preparations. Many of them exhibit wide spectra of biological effects, which are similar to those described for some groups of endogenous peptide bioregulators. The possibility of in vitro modeling of endogenous processes of proteolytic digestion of proteins that provides biologically active peptides is discussed.
Document emailed within 1 workday
Related Documents
Gmoshinskiĭ, I.V.; Zorin, S.N.; Kon', I.Ia.; Mazo, V.K. 1998: Proteolysis of immunoglobulins--biologically-active supplement in a fermented milk in gastrointestinal system of rats Voprosy Pitaniia 1998(4): 5-8Belagali, S.L.; Himaja, M.; Kumar, L.H.; Thomas, R.; Prakasini, S.R.; Poojary, B. 1999: (Nitro) hymenamide A, unusual biologically active cyclic peptide Bollettino Chimico Farmaceutico 138(4): 160-164
Reichelt, K.L.; Hole, K.; Hamberger, A.; Saelid, G.; Edminson, P.D.; Braestrup, C.B.; Lingjaerde, O.; Ledaal, P.; Orbeck, H. 1981: Biologically active peptide-containing fractions in schizophrenia and childhood autism Advances in Biochemical Psychopharmacology 28: 627-643
Medvedev, A.I.; Medvedeva, I.F.; Nazarova, L.F.; Mantsygin, I.A.; Smolianinov, V.V. 1975: Presence of biologically active glutamyl peptide in rabbit bone marrow Biulleten' Eksperimental'noi Biologii i Meditsiny 80(12): 84-86
Rambhav, S.; Ramachandran, L.K. 1976: Chemical modification of peptide antibiotics: Part IV--biologically active synthetic peptides and derivatives Indian Journal of Biochemistry and Biophysics 13(4): 361-364
Nakayama, K. 1995: A family of Kex2-like endoproteases involved in processing of precursors for biologically active peptides and proteins Seikagaku. Journal of Japanese Biochemical Society 67(8): 995-1009
Banach, W. 1986: Biologically active substances, other than antibodies, in preparations of normal human immunoglobulin. II. Placental proteins Medycyna Doswiadczalna i Mikrobiologia 38(4): 249-256
Kobayashi, I.; Ikeda, H. 1978: In vitro packaging of phage DNA--a new method for detection of biologically active DNA Seikagaku. Journal of Japanese Biochemical Society 50(3): 194-197
Mock, K. 1993: Routine sensitive peptide mapping using LC/MS of therapeutic proteins produced by recombinant DNA technology Peptide Research 6(2): 100-104
Lisitskaia, K.V.; Nikolaev, I.V.; Torkova, A.A.; Popov, V.O.; Koroleva, O.V. 2012: Analysis of functional properties of biologically active substances using eukaryotic cell models (review) Prikladnaia Biokhimiia i Mikrobiologiia 48(6): 581-599
Adaikan, P.G.; Zaman, V. 1982: In vitro activity of anthelmintic drugs and biologically active substances on Breinlia booliati Southeast Asian Journal of Tropical Medicine and Public Health 13(2): 257-261
Filippova, M.M.; Khachin, D.P.; Sazonova, O.V.; Blishchenko, E.I.; Iatskin, O.N.; Nazimov, I.V.; Karelin, A.A.; Ivanov, V.T.; Rasstrigin, N.A.; Pivnik, A.V. 2008: Fragments of functional proteins in the primary culture of human erythrocytes Bioorganicheskaia Khimiia 34(2): 160-170
Beliavskaia, V.A.; Timofeev, I.V.; Perminova, N.G.; Paletskaia, T.F.; Kozhina, E.M.; Zagrebel'nyĭ, S.N. 2000: Construction of an expression plasmid vector for accomplishing in vivo delivery of recombinant biologically active proteins. 2. Synthesis of HBcAG in a vaccine strain of Salmonella choleraesuis Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 3: 17-21
Blokhina, L.V.; Kochetkov, A.M. 2001: Functional constipation syndrome: experience in the use of sour milk products and biologically active food supplements in the complex treatment of patients Voprosy Pitaniia 70(1): 29-32
Johnstone, S.A.; Gelmon, K.; Mayer, L.D.; Hancock, R.E.; Bally, M.B. 2000: In vitro characterization of the anticancer activity of membrane-active cationic peptides. I. Peptide-mediated cytotoxicity and peptide-enhanced cytotoxic activity of doxorubicin against wild-type and p-glycoprotein over-expressing tumor cell lines Anti-Cancer Drug Design 15(2): 151-160
Pfleiderer, G.; Nagel, G.; Bühler, H. 1991: Limited proteolysis of lactate dehydrogenase from porcine heart with trypsin: characterization and reactivation of the fragments Experientia 47(5): 470-475
Jefferis, R.; Butwell, A.J.; Clamp, J.R. 1975: Studies on human IgD myeloma proteins. Carbohydrate composition of intact proteins and some proteolytic fragments Clinical and Experimental Immunology 22(2): 311-315
Paukovits, J.B.; Paukovits, W.R.; Laerum, O.D. 1986: Identification of a regulatory peptide distinct from normal granulocyte-derived hemoregulatory peptide produced by human promyelocytic HL-60 leukemia cells after differentiation induction with retinoic acid Cancer Research 46(9): 4444-4448
Adjobimey, T.; Edaye, I.; Lagnika, L.; Gbenou, J.; Moudachirou, M.; Sanni, A. 2004: Activités antiplasmodiales in vitro de quelques plantes antipaludiques de la pharmacopée béninoise : Les substances chimiques biologiquement actives extraites des plantes médicinales et les huiles essentielles des plantes aromatiques de la sous-région Ouest-Africaine - In vitro antiplasmodial activity of some antimalarial plants of beninese pharmacopoeia : Biologically active substances extracted from medicinal plants and essential oils from aromatic plants of West Africa Comptes Rendus. Chimie 7(10-11): 1023-1027
Clowes, G.H.; George, B.C.; Villee, C.A.; Saravis, C.A. 1995: Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. 1983 Nutrition 11(6): 775; Discussion 774; 776-777