Effects of glutamate and ATP on interleukin 6 production by cultured neonatal rat astrocyte
Wu, L.; Cao, Z.; Zhu, X.
Hunan Yi Ke Da Xue Xue Bao 22(2): 116-118
1997
ISSN/ISBN: 1000-5625 PMID: 9868050 Document Number: 474698
The effects of glutamate (Glu) and ATP on interleukin-6 (IL-6) production from cultured neonatal rat astrocyte were studied. Glu (100 apprx 200 mu-mol cntdot L-1) strongly increased, IL-6 production at 16h in a dose-dependent manner and ATP (50 apprx 100 mu-mol cntdot L-1) induced a inhibition effect. The results' suggest that Glu stimulated IL-6 release may be one of mechanisms of astrocyte "neuroprotective" function in ischemia/reperfusion.
Document emailed within 1 workday
Related Documents
Li, Z.; Lin, X-ming.; Gong, P-li.; Du, G-hua.; Zeng, F-dian. 2005: Effects of gingko biloba extract on glutamate-induced [Ca2+]i changes in cultured cortical astrocytes after hypoxia/reoxygenation, H2O2 or L-glutamate injury Yao Xue Xue Bao 40(3): 213-219Sakamoto, H.; Sakamaki, T.; Kanda, T.; Hirao, Y.; Ohyama, Y.; Ogishi, K.; Negishi, M.; Masuda, H.; Sumino, H.; Sawada, Y.; Ono, Z.; Kobayashi, I.; Nagai, R. 1997: Immunosuppressive drugs inhibit the production of interleukin-6 and interleukin-8 in cultured cardiac myxoma cells Research Communications in Molecular Pathology and Pharmacology 97(1): 60-66
Qiu, H.B.; Chen, D.C.; Pan, J.Q.; Liu, D.W.; Ma, S. 1999: Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages Zhongguo Yao Li Xue Bao 20(3): 271-275
Bennicelli, J.L.; Elias, J.; Kern, J.; Guerry, D. 1989: Production of interleukin 1 activity by cultured human melanoma cells Cancer Research 49(4): 930-935
Zhang, J.P.; Qian, D.H.; Qi, L.H. 1992: Effects of cantharidin on interleukin-2 and interleukin-1 production in mice in vivo Zhongguo Yao Li Xue Bao 13(3): 263-264
Henrotin, Y.E.; Labasse, A.H.; Simonis, P.E.; Zheng, S.X.; Deby, G.P.; Famaey, J.P.; Crielaard, J.M.; Reginster, J.Y. 1999: Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro Clinical and Experimental Rheumatology 17(2): 151-160
Visser, C.E.; Brouwer-Steenbergen, J.J.; Postmus, P.E.; Meijer, S.; Struijk, D.G.; Krediet, R.T.; Beelen, R.H. 1996: Renal function influences interleukin-8 background production by cultured human mesothelial cells Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis 12: 15-18
Lampa, J.; Klareskog, L.; Rönnelid, J. 2002: Effects of gold on cytokine production in vitro; increase of monocyte dependent interleukin 10 production and decrease of interferon-gamma levels Journal of Rheumatology 29(1): 21-28
Frei, K.; Bodmer, S.; Schwerdel, C.; Fontana, A. 1986: Astrocyte-derived interleukin 3 as a growth factor for microglia cells and peritoneal macrophages Journal of Immunology 137(11): 3521-3527
Wolf, R.E.; Hall, V.C. 1987: Interleukin-2 production and effect of thymosin fraction 5 on interleukin-2 production in rheumatoid arthritis Journal of Rheumatology 14(5): 898-901
Sun, Y.M.; Ho, M.L.; Hsu, H.K.; Peng, M.T. 1993: The effects of neonatal monosodium glutamate treatment on sex-odor attractivity and approach behavior in rats Gaoxiong Yi Xue Ke Xue Za Zhi 9(4): 232-242
Kierszenbaum, F.; Lopez, H.M.; Sztein, M.B. 1996: Trypanosoma cruzi downregulates the production of interleukin-2, interferon-gamma, interleukin-4 and interleukin-5 by activated human lymphocytes Journal of Parasitology 82(4): 652-656
Wissing, K.M.; Desalle, F.; Abramowicz, D.; Willems, F.; Leo, O.; Goldman, M.; Alegre, M.L. 1999: Down-regulation of interleukin-2 and interferon-gamma and maintenance of interleukin-4 and interleukin-10 production after administration of an anti-CD3 monoclonal antibody in mice Transplantation 68(5): 677-684
Drakes, M.L.; Harth, M.; Galsworthy, S.B.; McCain, G.A. 1987: Effects of gold on the production of and response to human interleukin-1 Journal of Rheumatology 14(6): 1123-1127
Kawasaki, T.; Ushiyama, T.; Inoue, K.; Hukuda, S. 2000: Effects of estrogen on interleukin-6 production in rheumatoid fibroblast-like synoviocytes Clinical and Experimental Rheumatology 18(6): 743-745
Zhong, M.; Cheng, G.; Wang, W.; Zhou, L.; Zhu, X.; Zhang, J. 1998: Effects of leukotrienes on production of interleukin 6 from mouse peritoneal macrophages Yao Xue Xue Bao 33(5): 326-329
Ikebe, T.; Hirata, M.; Koga, T. 1988: Effects of human recombinant tumor necrosis factor-alpha and interleukin 1 on the synthesis of glycosaminoglycan and DNA in cultured rat costal chondrocytes Journal of Immunology 140(3): 827-831
Aronica, E.; Dell'Albani, P.; Condorelli, D.F.; Nicoletti, F.; Hack, N.; Balázs, R. 1993: Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors Molecular Pharmacology 44(5): 981-989
Yamaguchi, M.; Yoshimoto, Y.; Komura, H.; Koike, K.; Matsuzaki, N.; Hirota, K.; Miyake, A.; Tanizawa, O. 1990: Interleukin 1 beta and tumour necrosis factor alpha stimulate the release of gonadotropin-releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells Acta Endocrinologica 123(4): 476-480
Xiao, W.M.; Yuan, K.Y.; Ynan, C. 2001: Effects of heat shock pretreatment on the translocation and expression of alpha B-crystallin in cultured neonatal rat cardiomyocytes Hunan Yi Ke da Xue Xue Bao 26(1): 1-3