Interleukin-2 production and effect of thymosin fraction 5 on interleukin-2 production in rheumatoid arthritis
Wolf, R.E.; Hall, V.C.
Journal of Rheumatology 14(5): 898-901
1987
ISSN/ISBN: 0315-162X PMID: 3123674 Document Number: 297303
Interleukin-2 (IL-2) production and effects of thymosin fraction 5 (F5) on IL-2 production by peripheral blood mononuclear cells from patients with active rheumatoid arthritis (RA) were studied. Three patients with RA had elevated IL-2 production which was which was suppressed by F5. IL-2 production by peripheral blood mononuclear cells from 17 other patients with RA was similar to controls and was not affected by F5. Our results are consistent with hyperproduction of IL-2 by some patients with RA which is suppressed by F5.
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