The effect of beta-carotene on the development of adjuvant arthritis and interleukin-1 production in rats
Potapova, A.A.; Buiuklinskaia, O.V.; Korsova, T.L.; Morozova, N.A.; Krivov, L.I.; Iakushina, S.M.; Poznanskaia, A.A.; Malakhova, E.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 116(12): 611-613
1993
ISSN/ISBN: 0365-9615 PMID: 8123819 Document Number: 412944
The production of interleukin 1 (IL1) by peritoneal and splenic macrophages from rats with adjuvant-induced arthritis on day 17 postadjuvant treatment was not altered compared with normal. Treatment of arthritic rats with beta-carotene reduced hind paw swelling and significantly increased ability of macrophages to secrete IL1 as well as stimulated spontaneous proliferation of splenic lymphocytes. No direct relationship between the release of IL1 from peritoneal and splenic macrophages and increase of hind paw swelling was revealed.