The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes
Buiuklinskaia, O.V.; Korostelev, S.A.; Potapova, A.A.; Sergeev, S.A.; Uteshev, B.S.
Voprosy Meditsinskoi Khimii 38(6): 29-31
1992
ISSN/ISBN: 0042-8809 PMID: 1298124 Document Number: 395542
Interleukin-2 (IL-2) production followed by with aftereffect of the immunosuppressive agent hydrocortisone and mitogen-induced proliferation of T lymphocytes were studied in the presence of artificial beta-carotene. Treatment of CBA mice with the drug was performed within various periods. beta-Carotene was found to elevate IL-2 secretion and the effect was both time- and dose-dependent. The drug removed immunosuppression developed after intraperitoneal administration of hydrocortisone. At the same time, beta-carotene stimulated mitogen-induced proliferation of T cells, which was dose-dependent.