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The effectiveness of inactivated, purified and concentrated experimental rabies vaccine for veterinary use: immunogenic activity

Süliová, J.; Benísek, Z.; Svrcek, S.; Durove, A.; Ondrejka, R.

Veterinarni Medicina 42(2): 51-56

1997

ISSN/ISBN: 0375-8427
PMID: 9127580
Document Number: 474464
An experimental, inactivated, concentrated and highly purified rabies vaccine was prepared from the strain Vnukovo-32/107. Simultaneous purification and concentration were carried out by affinity chromatography. The content of rabies antigen in the vaccine was 4.256 UE/cmsuperscript 3 (determined by an ELISA method). A lipoid adjuvant of the oil in water type and based on esters of fatty acids was used to restore the lyophilized vaccine to its original volume. Immunogenicity of the experimental preparation was compared with that of commercial rabies vaccines and reference vaccine by the NIH and NRLR methods. The results obtained (2.826 units/cmsuperscript 3 by the NIH and 3.085 units/cmsuperscript 3 by the NRLR method) confirmed that the method of affinity chromatography could be used to prepare a rabies vaccine that was superior to the commercial preparations available and complied with the WHO criteria.

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