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Therapeutic activity of the combined use of an interferon inducer and vaccine in experimental rabies

Gribencha, S.V.; Nosik, N.N.; Ershov, F.I.; Barinskiĭ, I.F.

Voprosy Virusologii 28(5): 590-594

1983

ISSN/ISBN: 0507-4088
PMID: 6659475
Document Number: 213336
Experiments in mice inoculated intramuscularly with a large dose of virulent street rabies virus demonstrated effectiveness of combined treatment with an interferon inducer (double-strand RNA) and vaccine. The treatment was started 24 hours after inoculation. The degree of protection of the animals treated by the combined method depended on the site of ds-RNA inoculation: intracerebral inoculation produced 58% protection (P less than 0.001), intravenous 35% (P less than 0,01), and intramuscular 21% (P less than 0.05). Vaccine alone was ineffective. Interferon inducer alone produced no significant protection which was due to the large infective dose of the virus.

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