Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer

Purcell, R.H.; London, W.T.; McAuliffe, V.J.; Palmer, A.E.; Kaplan, P.M.; Gerin, J.L.; Wagner, J.; Popper, H.; Lvovsky, E.; Wong, D.C.; Levy, H.B.; Purcell, R.H; London, W.T; McAuliffe, V.J; Palmer, A.E; Kaplan, P.M; Gerin, J.L; Wagner, J; Popper, H; Lvovsky, E; Wong, D.C; Levy, H.B

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Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer

Purcell, R.H.; London, W.T.; McAuliffe, V.J.; Palmer, A.E.; Kaplan, P.M.; Gerin, J.L.; Wagner, J.; Popper, H.; Lvovsky, E.; Wong, D.C.; Levy, H.B.

Lancet 2(7989): 757-761

1976

ISSN/ISBN: 0140-6736

PMID: 61440

Document Number: 100263

Chimpanzees chronically infected with hepatitis-B virus showed transient changes in several markers of infection when treated with the interferon inducer polyriboinosinic-polyribocytidylic acid-poly-l-lysine carboxymethyl cellulose. Serum Dane-particle-associated DNA polymerase, e antigen and hepatitis-B surface antigen, and intrahepatic hepatitis-B surface and core antigens diminished during treatment. Defective (DNA-polymerase-negative) Dane particles increased in titer transiently during treatment; these may play a role in the modulation of hepatitis-B virus infection. Humoral immune responses in chronic hepatitis-B carrier chimps were unaffected. Interferon inducers (or exogenous interferon) may be useful for the treatment of chronic hepatitis-B virus infection.