Clinical trials in healthy volunteers with the new purified chick embryo cell rabies vaccine for man
Bijok, U.; Barth, R.; Gruschkau, H.; Vodopija, I.; Smerdel, S.; Kukla, H.; Geursen, R.
Journal of Communicable Diseases 16(1): 61-69
1984
ISSN/ISBN: 0019-5138 PMID: 12055789 Document Number: 6360
Behringwerke has developed the new, safe and economical purified chick embryo cell (PCEC) rabies vaccine. Due to the purification by zonal centrifugation the compatibility of this vaccine is excellent. Among 933 vaccinations in 219 healthy volunteers the only side-effect was mild pain at the injection-site in 17 vaccinations (1.7 per cent). The sero-conversion of PCEC rabies vaccine was 100 per cent in the tested healthy volunteers. The kinetics of antibody induction after PCEC rabies vaccine is comparable to antibody induction after HDC rabies vaccine. PCEC rabies vaccine induces cellular immunity as measured in lymphocyte transformation test, but no interferon activity.
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