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Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases

Bhardwaj, M.; Bhattacharya, D.; Chhabra, M.; Ichhpujani, R.L.

Journal of Communicable Diseases 34(1): 40-42

2002

ISSN/ISBN: 0019-5138
PMID: 12718340
Document Number: 9134
The observations on immunogenicity of Purified Chick Embryo Cell (PCEC) anti rabies vaccination in post-exposure prophylaxis is reported. In total 207 serum samples collected from patients receiving 3 to 6 doses of PCEC were analysed for the presence of anti-rabies antibodies. The samples were collected from 10 days to 11 months after the last dose of vaccine. All the vaccinees (n=33) tested after 3 doses of PCEC showed protective titres (> or = 0.5 IU/ml) and those receiving 5-6 doses (n=161) showed 4-5 times higher than protective titres. The analysis pertains to specimens collected at one point of time only after the vaccination. However, in all 17 vaccinees where samples were collected 7-11 months after 3-6 doses of vaccine, the protective titres were sustained, these being 3-4 times higher than the protective titres in those receiving 5-6 vaccine doses. The results indicated that there was no need of routine anti-rabies antibody monitoring in healthy individuals receiving post-exposure prophylaxis in recommended doses of vaccine.

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Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases

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