The synthesis and pharmacological activities of C-galactosides of furanosequiterpenes
Chen, H.M.; Wang, Y.Y.; Mao, J.M.; Cai, M.S.; Jia, Z.J.
Yao Xue Xue Bao 32(10): 750-754
1997
ISSN/ISBN: 0513-4870 PMID: 11596217 Document Number: 473295
Four new C-galactosides were obtained by treatment of 1-O-trifluoroacetly-2, 3, 4, 6-tetra-O-benzly-alpha-D-galactopranose with 7-methoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran, 7-acetoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran and 1, 2-dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonist but their C-galactosides are calcium agonist.