Vascularization of the human embryonic neocortex in the rat anterior chamber under cyclosporine a immunosuppression
Puchkov, V.F.; Otellin, V.A.; Smirnov, E.B.
Morfologiia 110(5): 15-19
1996
ISSN/ISBN: 1026-3543 PMID: 9081594 Document Number: 469293
Fragments of 9 weeks hyman embryo neocortex were grafted into the rat eye anterior chamber. To prevent rejection cyclosporin A was introduced to the animals. Vascular network forming in transplants was studied for 5 weeks 3 days endothelial buds from the iris vessels appeared in transplants. After 10 days capillaries with erythrocytes appeared in the graft on the border with iris. 3 weeks later vascular network achieved its maximal development, occupying almost the entire graft thickness. The vessels developed diverged from the norm: they had variceal widenings, and focal distribution with significant non-vascular gaps.