Pharmacodynamics of cyclosporine-ketoconazole interaction in mice. Combined therapy potentiates cyclosporine immunosuppression and toxicity
Anderson, J.E.; Morris, R.E.; Blaschke, T.F.
Transplantation 43(4): 529-533
1987
ISSN/ISBN: 0041-1337 PMID: 3576671 Document Number: 298795
Ketoconazole (100 mg/kg daily) increased the immunosuppressive activity and toxicity of cyclosporine (25-200 mg/kg daily) in mice. Ketoconazole alone was not immunosuppressive. It is suggested that to avoid cyclosporine-induced nephrotoxicity, the dosage of cyclosporine should be decreased when ketoconazole and cyclosporine are used in combination.
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