Implantation of embryonic neocortex and spinal cord into injured peripheral nerve of adult rats
Chumasov, E.I.; Petrova, E.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 110(8): 198-201
1990
ISSN/ISBN: 0365-9615 PMID: 2291972 Document Number: 364838
Spinal cord and cerebral cortex of 14-day-old embryos of Wistar rats were implanted into the sciatic nerve of mature rats in order to study dynamics of the development of neuronal and neuroglial elements in ectopic sites. By means of light and electron microscopy it has been stated that the implanted nerve cells of the cortex and spinal cord survive during 5 month and differentiate from neuroepithelial cells and neuroblasts up to young and mature neurons. It was found that thirty days after operation the spinal cord implants contained myelinated nerve fibers and numerous synapses. The data obtained suggest that the implants of fetal spinal cord are more favorable for regeneration of the injured nervous stems than the cerebral cortex.