The cytodifferentiation of the rat spinal cord and neocortical neural elements when implanted into a peripheral nerve
Petrova, E.S.; Chumasov, E.I.
Tsitologiia 35(1): 59-64
1993
ISSN/ISBN: 0041-3771 PMID: 8475578 Document Number: 415287
Using electron microscopy, a study was made of the dynamics of development of the cerebral cortex and spinal cord in 14-day-old rat embryos implanted into the sciatic nerve of mature rats. It is shown that the implanted neural elements of the cortex and spinal cord survive for 8 months and differentiate from neuroepithelial cells and neuroblasts into young and mature neurons. In addition, the synaptogenesis and myelination were studied. Mature synapses in implants of the spinal cord were detected in 14 days, and in implants of the cortex in 21 days. The spinal cord and cortex implants displayed the first myelinated axons in 21 and 30 days, resp. Implants of the fetal spinal cord became mature earlier than the cortex implants. It has been stated that the processes of synaptogenesis and myelination in implants continue longer than in situ.