Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (II)
Khouili, M.; Guillaumet, G.; Coudert, G.; Pujol, M.D.
Farmaco 51(3): 185-188
1996
ISSN/ISBN: 0014-827X PMID: 8688140 Document Number: 459740
The four stereoisomers of compound 1 were synthesized from 2,3-dihydro-1, 4-benzodioxin and evaluated as alpha- and beta-adrenergic antagonists. Enantiomer 1-b [2R, 2'S] (Figure 1) is the best beta 1-blocking agent. Furthermore all compounds showed a alpha-blocking activity.
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