Conformational properties of benzodioxan derivatives with alpha-adrenergic blocking activity
Balsamo, A.; Macchia, B.; Macchia, F.; Martinelli, A.; Tognetti, P.; Veracini, C.A.
Molecular Pharmacology 20(2): 371-376
1981
ISSN/ISBN: 0026-895X PMID: 6117787 Document Number: 179801
Benzodioxan derivatives active on the .alpha.-adrenergic receptor are considered. The half-chair equilibrium of the dioxane ring was studied by 1H-NMR spectroscopy for piperoxan X and quiloflex XII. The preferred conformation was also obtained by PCILO calculations for X. The results were evaluated to obtain information on the mechanism of the .alpha.-adrenergic drug-receptor interaction.