Systemic and ocular effects of alpha 2-adrenergic stimulating and beta 2-blocking agents
Apponi-Battini, G.; Barra, A.; De Simone, C.; Rossi, F.; Berrino, L.; Cazzola, M.; Marmo, E.
Journal of Medicine 15(2): 126-134
1984
ISSN/ISBN: 0025-7850 PMID: 6150961 Document Number: 221923
The effects of alpha 2-adrenergic stimulating agents (clonidine and guanabenz) and beta-adrenolytic agents (atenolol and propranolol) on the systemic arterial pressure, heart-rate, blood glucose level and intraocular pressure, as well as on the concentrations of glucose, Na+, K+ and Ca++ in the lens and aqueous and vitreous humours, are evaluated in the rabbit. alpha 2-adrenergic stimulating agents cause a significant increase of the glucose concentration in the blood, lens, aqueous and vitreous humours; whereas the beta-adrenolytic agents cause insignificant effects. Neither of the two drugs alters the concentration of Na+, K+ and Ca++ in the lens and aqueous and vitreous humours.