Effects of calcium antagonists and beta-adrenergic receptor blocking agents on cardiovascular rhythmicity
Bellomo, G.; Santucci, S.; Murrone, A.; Santambrogio, L.; Gennari, M.; Stangoni, G.
Panminerva Medica 30(4): 236-239
1988
ISSN/ISBN: 0031-0808 PMID: 3244477 Document Number: 312419
The circadian rhythms of arterial blood pressure and heart rate were studied in 50 subjects divided in four groups, normotensive, untreated hypertensive, hypertensive treated with a calcium channel blocker or a beta adrenergic receptor blocking agent respectively. Cosinor analysis of the results showed that the patients treated with the calcium channel blocker exhibited a significantly higher amplitude of the circadian rhythms for both systolic and diastolic arterial blood pressure than the other groups. This finding might be important for the long-term treatment of hypertensive patients.