Elimination of virulence plasmids of Yersinia pseudotuberculosis as affected by fluoroquinolones
Zaĭtseva, E.A.; Shubin, F.N.; Besednova, N.N.
Antibiotiki i Khimioterapiia 41(6): 34-38
1996
ISSN/ISBN: 0235-2990 PMID: 9054327 Document Number: 459521
Pefloxacin, ciprofloxacin and norfloxacin were shown to induce elimination of the virulence plasmids in the strains of Y. pseudotuberculosis. Pefloxacin had a more pronounced eliminating effect than ciprofloxacin and norfloxacin. The elimination of the virulence plasmids with the molecular weight of 40-50 MD in the strains of Y. pseudotuberculosis was more frequent at the subinhibitory concentrations of the fluoroquinolones or at 1/4 of the fluoroquinolone MIC., At 1/8 of the MIC it was rarer. The virulence plasmid elimination in the strains was observed in spite of their serovar but was more frequent in the serovar 1B strains.