Treatment of accidental extravasation of antitumor agents with dimethylsulfoxide and alpha-tocopherol
Bonnetblanc, J.M.; Bordessoule, D.; Fayol, J.; Amici, J.M.
Annales de Dermatologie et de Venereologie 123(10): 640-643
1996
ISSN/ISBN: 0151-9638 PMID: 9615123 Document Number: 458611
The aim of this study was to test topical applications of dimethylsulfoxide and alpha-tocopherol for the prevention of ulcerations after antimitotic extravasation. An open prospective study was conducted in 10 patients in 4 different chemotherapy wards who had experienced infusion accidents leading to phlebitis (4 cases) or cellulitis (8 cases) including 2 at implant sites. Topical application of the dimethylsulfoxide alpha-tocopherol combination was initiated within the first hours and continued for 3 to 15 days. One patient was given dimethylsulfoxide alone. Necrosis was never observed. The implant sites were preserved and remained functional. The absence of secondary ulcerations and the preservation of the implant sites are clear advantages of this topical combination which should be used as first line treatment. Favorable results have been reported in the literature while other techniques used depend on the antimitotic agent and give variable results.