Amyloidosis in a dog: treatment with dimethylsulfoxide
Spyridakis, L.; Brown, S.; Barsanti, J.; Hardie, E.M.; Carlton, B.
Journal of the American Veterinary Medical Association 189(6): 690-691
1986
ISSN/ISBN: 0003-1488 PMID: 3759637 Document Number: 284099
A dog with hypoalbuminaemia, proteinuria, and renal amyloidosis was treated with dimethylsulphoxide (80 mg/kg, 3 times a week) for 2 years. During a 1-year period, serum albumin concentrations increased to within normal range. The 24-hour urinary protein excretion was 5.7 g before treatment with dimethylsulphoxide. Two years after initiation of treatment, the 24-hour urinary protein excretion was 3.7 g. Removal of a testicle containing a Sertoli cell tumour and treatment of interdigital pyoderma may have been factors in the dog's clinical improvement. The only adverse effect from the dimethylsulphoxide treatment was the characteristic disagreeable odour.