Studies of rhenium carboxylates as antitumor agents. Part II. Antitumor studies of bis (mu-propionato) diaquotetrabromodirhenium (III) in tumor-bearing mice
Eastland, G.W.; Yang, G.; Thompson, T.
Methods and Findings in Experimental and Clinical Pharmacology 5(7): 435-438
1983
ISSN/ISBN: 0379-0355 PMID: 6668962 Document Number: 197171
The neutral, dimeric complexes of rhenium, bis (mu-carboxalato)-diaquotetrahalodirhenium (III) (carboxalato = acetato, propionato, or butyrato and halo = chloro or bromo), were synthesized and survival studies were done on mice bearing P-388 leukemia or B-16 melanoma. The complex bis (mu-propionato) diaquotetrabromodirhenium (III) proved to be the most effective in increasing the life span of the mice. The complex showed some activity against B-16, but virtually none against P-388. The complexes are all quite non-toxic.