The interaction between two antioxidants, sodium ascorbate and gallic acid: radical intensity and apoptosis induction
Sakagami, H.; Satoh, K.
Anticancer Research 16(3a): 1231-1234
1996
ISSN/ISBN: 0250-7005 PMID: 8702242 Document Number: 456952
ESR spectroscopy revealed that both the radical intensity and degradation rate of sodium ascorbate were increased with increasing pH. Gallic acid significantly reduced the radical intensity of sodium ascorbate, which in turn reduced the radical intensity of gallic acid. Sodium ascorbate inhibited the apoptosis-inducing activity of gallic acid, and gallic acid inhibited the intracellular incorporation of ascorbic acid. These data suggest that interaction between sodium ascorbate and gallic acid might modify their biological activity.